multichannel extracellular amplifier digital lynx sx  (Neuralynx inc)

Journal: ACS Chemical Neuroscience

Article Title: Microinvasive Probes for Monitoring Electrical and Chemical Neural Activity in Nonhuman Primates

doi: 10.1021/acschemneuro.5c00071

Figure Lengend Snippet: In vivo FSCV and EPhys measurements from s-μIP from task-performing monkey T. (A) FSCV data collected from two neighboring sites using a dual-channel s-μIP, showing single-trial measurements as the monkey performed a forced choice large reward trial in the shape task (sites c8dg and c8ds: 483 days postimplant). Color plot shows clear dopamine redox current (i.e., color changes ∼0.6 and −0.2 V). PCA extracted dopamine concentration change ([ΔDA]) is plotted below the color plot and highlights changes around task events (e.g., increases in both channels after the value cue, V). (B) Single-trial LFP signals measured as monkey performed a large reward trial (top panel) in the direction task, with time plotted relative to value cue display at 0 s (site c3bs-c3a: 496 days postimplant). Top inset displays a close-up of the LFP signal where β bursts are visible (orange traces). The bottom panel is the β-band power to highlight task relevant changes in β signaling. For all figure panels, C indicates central cue, V is value cue display, and RW is reward outcome.

Article Snippet: During each recording session, a 4 channel FSCV system was used to record dopamine from a subset of implanted electrodes, and an EPhys system (Neuralynx, Digital Lynx SX) was connected to all remaining electrodes, as done in previously reported experiments., The Ag/AgCl electrodes implanted above the epidural tissue and inside the EPhys were connected to the FSCV system ground and used as the reference for both the FSCV and EPhys recordings.

Techniques: In Vivo, Concentration Assay